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Recombinant Anti-Claudin 1 Mouse mAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Claudin-1 |
Synonyms: | CLDN1, CLD1, ILVASC, SEMP1, claudin 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human claudin 1 |
Uniprot ID: | O95832 |
Isotype: | IgG1 |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 500-1: 1000 | skin, cervical squamous carcinoma |
Background
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.Acts as a co-receptor for hepatitis C virus in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus.
Images
| Immunohistochemistry analysis of paraffin embedded human cervical squamous carcinoma using Claudin 1 (GB15032) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse skin using Claudin 1 (GB15032) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded rat skin using Claudin 1 (GB15032) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
