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Anti-Claudin 15 Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Claudin-15 |
Synonyms: | CLDN15 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Claudin 15 |
Uniprot ID: | Q9Z0S5 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 24 kDa / 22 kDa |
Product Usage Information
WB | Rat | 1: 1000-1: 2000 | small intestine |
Background
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake.
Images
| Western blot analysis of CLDN15 (GB114914) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
