Your shopping cart is empty!
Anti-Cyclin D3/CCND3 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Cyclin D3 rabbit polyclonal antibody |
Gene Name: | G1/S-specific cyclin-D3 |
Synonyms: | Ccnd3, Cyl-3, CyclinD3, D3 type cyclin, G1 S specific cyclin D3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Cyclin D3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 32 kDa |
Observed MW. | 32 kDa |
Uniprot ID: | P30281, P30282, P48961 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | liver, kidney |
Background
Cyclin D3 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.
Images
|
|
Western blot analysis of Cyclin-D2 (GB111250) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
