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Anti-Cyp26B1 Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Cytochrome P450 26B1 |
Synonyms: | CYP26A2, CYP26B1, Cytochrome P450 26A2, Cytochrome P450 26B1, Cytochrome P450RAI 2, P450RAI 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Cyp26B1 |
Uniprot ID: | Q811W2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 57 kDa / 60 kDa |
Product Usage Information
WB | Human, Mouse | 1: 800-1: 1500 | brain |
Background
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation . Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA . Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA . Essential for postnatal survival . Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis .
Images
| Western blot analysis of CYP26B1 (GB114603) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
