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Anti-DAPP1 Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DAPP1 rabbit polyclonal antibody |
Gene Name: | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide |
Synonyms: | BAM32, DAPP1, hDAPP1, B lymphocyte adapter protein Bam32 |
Immunogen: | Recombinant protein corresponding to Mouse DAPP1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 32 kDa |
Observed MW. | 32 kDa |
Uniprot ID: | Q9QXT1 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Rat | 1: 3000-1: 6000 | liver |
Background
DAPP1 was identified as dual adaptor for phosphotyrosine and 3-phosphoinositides, a novel 280 amino acid protein which contains a putative myristoylation site at its N-terminus followed by a SH2 and a PH domain at its C-terminus (PMID: 10432293). DAPP1 is also referred to B cell adaptor molecule of 32 kDa (Bam32), and is expressed by B lymphocytes, but not T lymphocytes or nonhematopoietic cells. DAPP1/Bam32 was shown to regulate BCR signaling downstream of phosphatidylinositol 3-kinase (PI3K) (PMID: 10770799). Furthermore, DAPP1/Bam32 may server to integrate PI3K and Src kinase signaling to promote Rac-dependent B cell adhesive interactions important for antigen presentation function (PMID: 20495066).
Images
 | Western blot analysis of DAPP1 (GB113992) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
