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Anti-DNA polymerase eta Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DNA polymerase eta rabbit polyclonal |
Gene Name: | DNA polymerase eta |
Synonyms: | POLH, polymerase (DNA directed), eta, RAD30, RAD30 homolog A, RAD30A, XP-V, XPV, FLJ16395, FLJ21978, Xeroderma pigmentosum variant type protein homolog |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse DNA polymerase eta |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 76 kDa |
Observed MW. | 46 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 2000-1: 4000 | liver, kidney |
Background
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
Images
| Western blot analysis of POLH (GB113678) at dilution of 1: 4000 |
| Western blot analysis of POLH (GB113678) at dilution of 1: 4000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
