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Anti-DYRK1A Rabbit pAb (100 μl)
| Reactivity: | H,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DYRK1A rabbit polyclonal |
Gene Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
Synonyms: | Dual specificity YAK1-related kinase, MP86, Protein kinase minibrain homolog, MNBH, Dyrk1a, Dyrk, HP86, MRD7, MNB, MNB protein kinase, Serine/threonine kinase MNB |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse DYRK1A |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 85 kDa |
Observed MW. | 85 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Rat | 1: 500-1: 1000 | skeletal muscle |
Background
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 . Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis.
Images
 | Western blot analysis of DYRK1A (GB113233) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
