Anti-Dnmt1 Rabbit pAb (100 μl)

Anti-Dnmt1 Rabbit pAb (100 μl)

Brand: ServiceBio
Cat. #: GB11328-100
Availability: In Stock
$259.00
-+
Reactivity: H,M    
Applications: WB    
Host Species: Rabbit    
Clonality: Polyclonal    
Full Name:

Dnmt1 rabbit polyclonal antibody

Gene Name:

DNA (cytosine-5)-methyltransferase 1

Synonyms:

DNA (cytosine-5-)-methyltransferase 1,DNA methyltransferase 1, DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI

Immunogen:

KLH conjugated Synthetic peptide corresponding to Mouse Dnmt1

Isotype:

IgG

Purity:

Affinity purification

Subcellular location:

Nucleus

Uniprot ID:

P13864, P26358




Product Usage Information

Applications

Species

Dilution

Positive Sample

IHC/IF

Human

1: 500-1: 2000

colon, kidney, lung, stomach, thyroid gland




Background

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2.




Images


Immunohistochemistry analysis of paraffin-embedded human lung cancer  using Dnmt1 (GB11328) at dilution of 1:800

Immunohistochemistry analysis of paraffin-e mbedded human liver cancer  using Dnmt1 (GB11328) at dilution of 1:800

Immunohistochemistry of paraffin embedded human lung using Dnmt1 (GB11328) at dilution of 1:1000 (400x lens)


Immunofluorescence of paraffin embedded human stomach using Dnmt1 (GB11328) at dilution of 1:500 (400x lens)

Immunofluorescence of paraffin embedded human thyroid gland using Dnmt1 (GB11328) at dilution of 1:500 (400x lens)




Storage

Storage Store at -20°C for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


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