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Anti-EPHA8 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Ephrin type-A receptor 8 |
Synonyms: | EEK, EK3, EPH and ELK related kinase, EPH like kinase 3, EPH receptor A8, EPHA8, Ephrin type A receptor 8, HEK3, KIAA1459 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse EPHA8 |
Uniprot ID: | O09127 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 111 kDa / 110 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 800-1: 1500 | brain, kidney |
Background
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.
Images
| Western blot analysis of EPHA8 (GB115329) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
