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Anti-EXOSC7 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Exosome complex exonuclease RRP42 |
Synonyms: | EAP1, EXOSC7, exosome component 7, hRrp42p, KIAA0116, p8, RRP42, Rrp42p |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse EXOSC7 |
Uniprot ID: | Q9D0M0 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Product Usage Information
IHC/IF | Mouse | 1: 400-1: 1200 | colon, ovary |
Background
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates.
Images
| Immunohistochemistry analysis of paraffin embedded mouse colon using EXOSC7 (GB114941) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin embedded mouse ovary using EXOSC7 (GB114941) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
