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| Reactivity: | M & H |
| Applications: | IHC/IF & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Arachidonate 5-lipoxygenase-activating protein |
Synonyms: | DNase IV, FEN 1, FEN1, Flap endonuclease 1, flap structure endonuclease 1, hFEN 1, Maturation factor 1, MF1, RAD2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FLAP |
Uniprot ID: | P30355 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Membrane |
Product Usage Information
IHC/IF | Mouse | 1: 500-1: 2000 | lung, kidney, spleen |
ICC/IF | Human | 1: 100-1: 600 | HeLa |
Background
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity).
Images
| Immunohistochemistry analysis of paraffin embedded mouse kidney using FLAP (GB115057) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded mouse spleen using FLAP (GB115057) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded mouse lung using FLAP (GB115057) at dilution of 1: 600 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed Hela cells using FLAP (GB115057) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
