Your shopping cart is empty!
Anti-Fas Ligand Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Fas Ligand rabbit polyclonal antibody |
Gene Name: | Tumor necrosis factor ligand superfamily member 6 |
Synonyms: | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FASL |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 31 kDa |
Observed MW. | 31 kDa |
Uniprot ID: | P48023, P41047, P36940 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | breast cancer, liver, spleen, brain |
Background
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells . Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development . Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways . Can induce apoptosis but does not appear to be essential for this process.
Images
|
|
Western blot analysis of FASL (GB11090) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
