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Anti-Flt3 / CD135 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Flt3 rabbit polyclonal antibody |
Gene Name: | Receptor-type tyrosine-protein kinase FLT3 |
Synonyms: | FL cytokine receptor, Fetal liver kinase 2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Tyrosine-protein kinase receptor flk-2, CD135, Flt3, Flk-2, Flt-3 |
Immunogen: | Recombinant protein corresponding to Mouse Flt3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. | 113 kDa |
Observed MW. | 130/160 kDa |
Uniprot ID: | P36888, Q00342 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | liver, thymus, spleen |
IHC/IF | Mouse, Rat | 1: 1000-1: 4000 | bone, brain, liver, placenta, spleen, testis |
Background
FLT3 (also known as CD135 or FLK2) is a tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. FLT3 was originally identified by its expression in hematopoietic stem/progenitor cells . It is important for the normal development of hematopoietic stem/progenitor cells. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Images
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Western blot analysis of FLT3 (GB111358) at dilution of 1: 500 |
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Immunohistochemistry of paraffin embedded mouse brain using FLT3 (GB111358) at dilution of 1: 4400 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse spleen using FLT3 (GB111358) at dilution of 1: 4400 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using FLT3 (GB111358) at dilution of 1: 4400 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using FLT3 (GB111358) at dilution of 1: 4400 (400x lens) |
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Immunofluorescence of paraffin embedded mouse bone using FLT3 (GB111358) at dilution of 1: 2200 (400x lens) |
| Immunofluorescence of paraffin embedded mouse brain using FLT3 (GB111358) at dilution of 1: 2200 (400x lens) |
| Immunofluorescence of paraffin embedded mouse liver using FLT3 (GB111358) at dilution of 1: 2200 (400x lens) |
| Immunofluorescence of paraffin embedded mouse placenta using FLT3 (GB111358) at dilution of 1: 2200 (400x lens) |
| Immunofluorescence of paraffin embedded mouse testis using FLT3 (GB111358) at dilution of 1: 2200 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |