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| Reactivity: | M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GATM rabbit polyclonal |
Gene Name: | Glycine amidinotransferase, mitochondrial |
Synonyms: | AGAT, AT, GATM, Transamidinase, L-arginine:glycine amidinotransferase |
Immunogen: | Recombinant protein corresponding to Mouse GATM |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 48 kDa |
Observed MW. | 44 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 1000-1: 3000 | kidney, pancreas |
Background
GATM, also known as AGAT, produces ornithine and guanidinoacetate (GAA) from arginine and glycine, and is a key enzyme for creatine synthesis. GATM deficiency in early infancy causes neurodevelopmental delay. GATM is predominantly expressed in kidney and pancreas in adults. Decrease of GAMT proteins was observed in proximal tubule damage cases, which links GATM as a general marker for proximal tubule damage. Alternative splicing of GATM generates three isoforms with molecular weights between 44 kDa to 48 kDa.
Images
 | Western blot analysis of GATM (GB113430) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
