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| Reactivity: | H,M,R & H,M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GIT2 rabbit polyclonal |
Gene Name: | ARF GTPase-activating protein GIT2 |
Synonyms: | ARF GAP GIT2, GRK-interacting protein 2, Git2, Cool-interacting tyrosine-phosphorylated protein 2, CAT-2, G protein-coupled receptor kinase-interactor 2 |
Immunogen: | Recombinant protein corresponding to Mouse GIT2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 1000-1: 4000 | colon, breast cancer, small intestine |
IF | Human, Mouse, Rat | 1: 500-1: 1000 | colon, breast cancer, small intestine |
Background
This gene encodes a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. This gene undergoes extensive alternative splicing; although ten transcript variants have been described, the full length sequence has been determined for only four variants. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
Images
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Immunohistochemistry analysis of paraffin-embedded human colon using GIT2 (GB111092) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded human breast cancer using GIT2 (GB111092) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded rat small intestine using GIT2 (GB111092) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
