Your shopping cart is empty!
Anti-GPCR GPR120 Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GPCR GPR120 rabbit polyclonal |
Gene Name: | Free fatty acid receptor 4 |
Synonyms: | G-protein coupled receptor 120, G-protein coupled receptor GT01, Omega-3 fatty acid receptor 1, Gpr120, O3far1, Ffar4 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GPR120 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Endosome, Lysosome |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1000-1: 2000 | pancreas, white fat, pituitary gland |
IF | Mouse, Rat | 1: 1000-1: 2000 | pituitary, epididymis, testis |
Background
GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of glucagon-like peptide 1 (GLP-1) in vivo and in vitro. GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake. GLP-1 also inhibits glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion of GLP-1 is critical in the treatment of diabetes.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse pancreas using GPR120 (GB112533) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded mouse white fat using GPR120 (GB112533) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded rat white fat using GPR120 (GB112533) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded mouse pituitary gland using GPR120 (GB112533) at dilution of 1: 2000 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse pituitary using GPR120 (GB112533) at dilution of 1: 2000 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse epididymis using GPR120 (GB112533) at dilution of 1: 2000 |
 | Immunofluorescent analysis of paraformaldehyde-fixed rat testis using GPR120 (GB112533) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
