Your shopping cart is empty!
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GPX1 rabbit polyclonal antibody |
Gene Name: | Glutathione peroxidase 1 |
Synonyms: | GPX1, GPXD, GSHPX1, glutathione peroxidase 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GPX1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 22 kDa |
Observed MW. | 22 kDa |
Uniprot ID: | P11352, P04041 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | liver, spleen, kidney |
Background
As a glutathione peroxidase, GPx1 functions in the detoxification of hydrogen peroxide, specifically by catalyzing the reduction of hydrogen peroxide to water. The glutathione peroxidase also catalyzes the reduction of other organic hydroperoxides, such as lipidperoxides, to the corresponding alcohols.GPx1 typically uses glutathione (GSH) as the reductant, but when glutathione synthetase (GSS) is, as in brain mitochondria, γ-glutamylcysteine can serve as the reductant instead.The protein encoded by this gene protects from CD95-induced apoptosis in cultured breast cancer cells and inhibits 5-lipoxygenase in blood cells, and its overexpression delays endothelial cell death and increases resistance to toxic challenges, especially oxidative stress.This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA.
Images
|
Western blot analysis of GPX1 (GB11291) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
