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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HGD rabbit polyclonal |
Gene Name: | Homogentisate 1,2-dioxygenase |
Synonyms: | AKU, HGD, HGO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase |
Immunogen: | Recombinant protein corresponding to Mouse HGD |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 50 kDa |
Observed MW. | 48 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 300-1: 1000 | stomach, liver |
Background
Homogentisate1,2-dioxygenase (HGD), also named as HGO, is a mononuclear Fe(II)-dependent oxygenase that catalyzes the third step in the pathway for the catabolism of tyrosine, the conversion of homogentisate (HG) to maleylacetoacetate (MAA) and it can exsit as a dimer or trimer. HGD consists of a single type of subunit with no intermolecular disulfide bridges and requires Fe2+ as a cofactor. Defects in HGD are the cause of alkaptonuria (AKU).
Images
 | Western blot analysis of HGD (GB113641) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
