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Anti-HSD17B8 Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | (3R)-3-hydroxyacyl-CoA dehydrogenase |
Synonyms: | 17 beta HSD 8, D6S2245E, FABG, FABGL, H2 KE6, HKE6, HSD17B8, Ke 6, KE6, Protein Ke6, RING2, SDR30C1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HSD17B8 |
Uniprot ID: | P50171 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Mitochondrion matrix |
Predicted MW. / Observed MW. | 27 kDa / 32 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 2000-1: 3000 | kidney, liver, placenta |
IHC/IF | Mouse, Rat | 1: 1000-1: 3000 | brain |
Background
Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex, acts as scaffold protein, required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference, this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD+(H).
Images
| Western blot analysis of RING2 (GB114804) at dilution of 1: 2000 |
| Immunohistochemistry of paraffin embedded mouse Brain using RING2 (GB114804) at dilution of 1: 1000 |
| Immunohistochemistry of paraffin embedded rat Brain using RING2 (GB114804) at dilution of 1: 1000 |
| Immunofluorescence of paraffin embedded rat Brain using RING2 (GB114804) at dilution of 1: 300 |
| Immunofluorescence of paraffin embedded mouse Brain using RING2 (GB114804) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
