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Anti-IGF1 Receptor Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Insulin-like growth factor 1 receptor |
Synonyms: | Insulin-like growth factor I receptor, IGF-I receptor, CD221, MGC142170, JTK13, CD221 antigen, IGFIRC, Insulin like growth factor 1 receptor precursor |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human IGF1 Receptor |
Uniprot ID: | P08069 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 400-1: 800 | breast cancer, kidney, heart |
Background
IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cell. IGF1R is a heterotetrameric receptor, composed of two alpha subunits (130 kDa each) and two beta subunits (~98 kDa each) .
Images
| Immunohistochemistry analysis of paraffin embedded human breast cancer using IGF1R (GB115049) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded human breast cancer using IGF1R (GB115049) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded mouse heart using IGF1R (GB115049) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using IGF1R (GB115049) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded rat heart using IGF1R (GB115049) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded rat kidney using IGF1R (GB115049) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
