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Anti-IL-1 beta Rat mAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | |
| Clonality: | |
| Gene Name: | Interleukin-1 beta |
Synonyms: | IL1B, IL-1, IL1-BETA, IL1F2, interleukin 1 beta |
Immunogen: | Recombinant protein corresponding to Mouse IL-1 beta |
Uniprot ID: | P10749 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 31 kDa / 28/35 kDa |
Product Usage Information
Applications | Species | Dilution | Positive Tissue |
WB | Mouse | 1: 300-1: 500 | RAW264.7 |
Background
Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Images
| WB analysis of IL-1 beta(GB125602). |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
