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Anti-Influenza Virus NS1A Binding Protein Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Influenza virus NS1A-binding protein homolog |
Synonyms: | ARA3, FLARA3, HSPC068, IVNS1ABP, KIAA0850, ND1, NS 1, NS1, NS1 binding protein, NS1 BP, NS1BP |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Influenza Virus NS1A Binding Protein |
Uniprot ID: | Q920Q8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 1200-1: 3600 | colon, kidney, brain |
Background
Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro).; [Isoform 2]: May play a role in cell cycle progression in the nucleus.
Images
| Immunohistochemistry analysis of paraffin embedded mouse kidney using IVNS1ABP (GB114944) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin embedded mouse colon using IVNS1ABP (GB114944) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin embedded mouse brain using IVNS1ABP (GB114944) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin embedded rat brain using IVNS1ABP (GB114944) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin embedded rat brain using IVNS1ABP (GB114944) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin embedded rat colon using IVNS1ABP (GB114944) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin embedded rat kidney using IVNS1ABP (GB114944) at dilution of 1: 3600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
