Your shopping cart is empty!
Anti-Insig1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Insulin-induced gene 1 protein |
Synonyms: | CL 6, INSIG-1, INSIG1, insulin induced gene 1, Insulin induced gene 1 protein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Insig1 |
Uniprot ID: | Q8BGI3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 28 kDa / 35 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 800-1: 1500 | liver |
Background
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR . Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum . In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi.
Images
| Western blot analysis of INSIG1 (GB114751) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
