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Anti-Integrin beta 1 Rabbit pAb (100 μl)
| Reactivity: | H,M & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Integrin beta-1 |
Synonyms: | Integrin beta-1, Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, VLA-4 subunit beta, CD29, ITGB1, FNRB, MDF2, MSK12 |
Immunogen: | Recombinant protein corresponding to Human CD29 |
Uniprot ID: | P05556 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. / Observed MW. | 88 kDa / 130-150 kDa |
Product Usage Information
WB | Human, Mouse | 1: 300-1: 600 | kidney, sleen |
IHC/IF | Human | 1: 300-1: 600 | esophageal cancer, breast cancer, liver, leiomyosarcoma, colon, placenta, tonsil |
Background
Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor. This integrin associates with integrins alpha 1 and 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. Integrin beta 1 is expressed as at least four different isoforms. In cardiac muscle and skeletal muscle, the integrin beta-1 isoform is specifically expressed, and localizes to costameres, where it aids in the lateral force transmission from the Z-discs to the extracellular matrix. Abnormal levels of integrin beta-1 have been found in limb girdle muscular dystrophy and polyneuropathy.
Images
| Western blot analysis of CD29 (GB115173) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded human breast cancer using CD29 (GB115173) at dilution of 1: 300 |
| Immunohistochemistry analysis of paraffin embedded human esophageal cancer using CD29 (GB115173) at dilution of 1: 300 |
| Immunohistochemistry analysis of paraffin embedded human leiomyosarcoma using CD29 (GB115173) at dilution of 1: 300 |
| Immunohistochemistry analysis of paraffin embedded human colon using CD29 (GB115173) at dilution of 1: 300 |
| Immunohistochemistry analysis of paraffin embedded human tonsil using CD29 (GB115173) at dilution of 1: 300 |
| Immunohistochemistry analysis of paraffin embedded human placenta using CD29 (GB115173) at dilution of 1: 300 |
| Immunohistochemistry analysis of paraffin embedded human liver using CD29 (GB115173) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
