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Anti-KLHL12 Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Kelch-like protein 12 |
Synonyms: | C3IP1, CUL3 interacting protein 1, DKIR, kelch like 12 (Drosophila), Kelch like protein 12, KLHL12 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse KLHL12 |
Uniprot ID: | Q8BZM0 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 63 kDa / 63 kDa |
Product Usage Information
WB | Human, Mouse | 1: 300-1: 600 | testis, kidney |
Background
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B).
Images
| Western blot analysis of KLHL12 (GB114655) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
