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Anti-LARP1 Rabbit pAb (100 μl)
| Reactivity: | M & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | La-related protein 1 |
Synonyms: | KIAA0731, La related protein 1, LARP |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LARP1 |
Uniprot ID: | Q6ZQ58 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. / Observed MW. | 121 kDa / 150 kDa |
Product Usage Information
WB | Mouse | 1: 2000-1: 3000 | pancreas |
IHC/IF | Human, Mouse, Rat | 1: 700-1: 2100 | liver, kidney, colon cancer, colon |
Background
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1.
Images
| Western blot analysis of LARP1 (GB115191) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded mouse liver using LARP1 (GB115191) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded rat liver using LARP1 (GB115191) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using LARP1 (GB115191) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded rat kidney using LARP1 (GB115191) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded human kidney using LARP1 (GB115191) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded human colon cancer using LARP1 (GB115191) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded human colon using LARP1 (GB115191) at dilution of 1: 700 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
