Your shopping cart is empty!
-23%
Anti-LC3B Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Microtubule-associated proteins 1A/1B light chain 3B |
Synonyms: |
LC3, LC3B, MAP1A/1BLC3, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, MAP1ALC3, MAP1LC3B |
Immunogen: |
KLH conjugated Synthetic peptide corresponding to Mouse LC3B |
Uniprot ID: |
Q9GZQ8, Q62625, Q9CQV6 |
Isotype: |
IgG |
Purity: |
Affinity purification |
Subcellular location: |
Cytoplasm |
Predicted MW. / Observed MW. |
14/16 kDa / 14/16 kDa |
Product Usage Information
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
Hela, NIT/3T3 |
Background
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Images
|
Western blot analysis of LC3 (GB113801) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
