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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MCM3 rabbit polyclonal |
Gene Name: | DNA replication licensing factor MCM3 |
Synonyms: | DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, Mcm3, Mcmd, Mcmd3, HCC5, P1.h, p102, RLF subunit beta, RLFB |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MCM3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 92 kDa |
Observed MW. | 105 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
| WB | Human, Mouse, Rat | 1: 800-1: 1600 | K562, L6, Raw264.7, PC-12 |
Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
Images
 | Western blot analysis of MCM3 (GB112992) at dilution of 1: 1600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
