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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MLK4 rabbit polyclonal antibody |
Gene Name: | Mitogen-activated protein kinase kinase kinase 21 |
Synonyms: | Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4, Map3k21, Kiaa1804, Mlk4 |
Immunogen: | Recombinant protein corresponding to Mouse MLK4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 110 kDa |
Observed MW. | 120 kDa |
Uniprot ID: | Q8VDG6, D4A454 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | heart |
Background
MLK4 belongs to the MAP kinase subfamily. The MLK family members are characterized by the presence of signature sequences of Ser/Thr and Tyr kinases within their catalytic domain. The MLK1-4 contains an aminoterminal Src-Homology (SH3) domain, followed by the kinase domain, a leucine-zipper region, and a Cdc42/Rac-interactive binding (CRIB) motif. MLK4 expressed in two splicing variants, MLK4α and MLK4β. The difference of these two isoforms is located in their C-terminal portion. The negative effect of MLK4 on LPS-induced ERK and JNK activation could be very important in controlling the level of cytokine expression, and thus maintaining the balance of inflammatory responses.
Images
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Western blot analysis of mlk4 (GB111071) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |