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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Myelin regulatory factor [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal] |
Synonyms: | C11orf9, MRF, Ndt80, pqn-47 |
Immunogen: | Recombinant protein corresponding to Mouse MYRF |
Uniprot ID: | Q3UR85 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 123 kDa / 120 kDa |
Product Usage Information
WB | Human | 1: 300-1: 500 | Hep G2, 293T, HeLa |
Background
[Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes.; [Myelin regulatory factor, C-terminal]: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.; [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination . Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype.
Images
| Western blot analysis of MYRF (GB114426) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
