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Anti-Mob1A Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | MOB kinase activator 1A |
Synonyms: | MATS2, Mob1 homolog 1A, Mob1A, Mob1B, MOB4A, MOBKL1A, Protein Mob4A |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Mob1A |
Uniprot ID: | Q921Y0 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 25 kDa / 25 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 400-1: 800 | ovary, small intestine |
Background
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity).
Images
| Western blot analysis of Mob1A (GB114314) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
