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Anti-NALP2 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | NACHT, LRR and PYD domains-containing protein 2 |
Synonyms: | CLR19.9, NALP2, NBS1, NLRP2, PAN1, PYPAF2 |
Immunogen: | Recombinant protein corresponding to Human NALP2 |
Uniprot ID: | Q9NX02 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 121 kDa / 105-120 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | HT-29, 293T, PC3, A549, HeLa |
Background
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases.
Images
| Western blot analysis of NLRP2 (GB114502) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
