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Anti-NAP1L2 Rabbit pAb (100 μl)
| Reactivity: | H,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Nucleosome assembly protein 1-like 2 |
Synonyms: | Bpx, Nap1l2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse NAP1L2 |
Uniprot ID: | P51860 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
IHC/IF | Human, Rat | 1: 700-1: 2100 | brain, kidney |
Background
Proper nucleosome assembly is critical for compacting DNA into chromatin. In human and mouse there are 5 protein-coding genes which comprise the nucleosome assembly protein (NAP) family.The remaining three family members, NAP1L2, NAP1L3 and NAP1L5 are neuron-specific nucleosome assembly proteins translated from intronless genes which are monoallelically expressed. NAP1L2 (nucleosome assembly protein 1-like 2), also known as BPX (brain specific protein, X-linked), is a 460 amino acid protein containing acidic domains which are thought to mediate histone interactions. NAP1L2 binds to chromatin and interacts with Histones H3 and H4. The function of NAP1L2 is not clearly defined although evidence suggests that NAP1L2 influences histone acetylation and therefore may play a significant role in regulating transcription in developing neurons.
Images
| Immunohistochemistry analysis of paraffin embedded rat brain using NAP1L2 (GB115318) at dilution of 1:700 |
| Immunohistochemistry analysis of paraffin embedded human kidney using NAP1L2 (GB115318) at dilution of 1:700 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
