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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NK-1R rabbit polyclonal antibody |
Gene Name: | Substance-P receptor |
Synonyms: | Tacr1, TACR1, NK1R, NKIR, SPR, TAC1R, Tachykinin receptor 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TACR1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 46 kDa |
Observed MW. | 46 kDa |
Uniprot ID: | P25103, P30548, P14600 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | brain, heart, spinal cord |
Background
The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. It is probably associated with G proteins that activate a phosphatidylinositol calcium second messenger system. The endogenous ligand for this receptor is Substance P. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. The binding of SP to the NK1 receptor has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation.
Images
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Western blot analysis of TACR1 (GB11759) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
