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Anti-N myc interactor/NMI Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | N-myc-interactor |
Synonyms: | N-myc and STAT interactor, Nmi |
Immunogen: | Recombinant protein corresponding to Mouse N myc interactor/NMI |
Uniprot ID: | O35309 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 35 kDa / 40 kDa |
Product Usage Information
WB | Mouse | 1: 500-1: 1000 | heart, liver |
Background
Acts as a signaling pathway regulator involved in innate immune system response . In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis . Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription . In response to interferon IFN-alpha, associates in a complex with transcriptional regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 .
Images
| Western blot analysis of NMI (GB114586) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
