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Anti-NR0B2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NR0B2 rabbit polyclonal |
Gene Name: | Nuclear receptor subfamily 0 group B member 2 |
Synonyms: | Orphan nuclear receptor SHP, Small heterodimer partner, Nr0b2, Shp, Nr0b2a, Shp1, |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse NR0B2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 800-1: 1600 | testis, kidney |
Background
SHP is an orphan nuclear receptor containing the dimerization and ligand-binding domains found in other nuclear receptors, but lacking the conserved DNA binding domain. SHP is specifically expressed in liver and other tissues, including fetal liver and adrenal gland, as well as adult spleen and small intestine. In addition, SHP is highy expressed in the murine macrophage cell line RAW 264.7 but suppressed by oxLDL and 13-HODE, which is a ligand for PPARg. SHP interacts with nuclear receptors, including thyroid receptor, retinoic acid receptors (RAR and RXR) and estrogen receptors (ERa and ERb). SHP functions as a negative regulator of these receptors by at least three mechanisms: inhibition of DNA binding via dimerization, direct antagonism of coactivator function through competition and possibly transrepression via recruitment of putative corepressors.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse testis using NR0B2 (GB113097) at dilution of 1: 1600 |
| Immunohistochemistry analysis of paraffin-embedded rat testis using NR0B2 (GB113097) at dilution of 1: 1600 |
| Immunohistochemistry analysis of paraffin-embedded rat kidney using NR0B2 (GB113097) at dilution of 1: 1600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
