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Anti-Nogo Receptor Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Reticulon-4 receptor |
Synonyms: | NGR, Nogo 66 receptor, NOGOR, reticulon 4 receptor, RTN4R |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Nogo Receptor |
Uniprot ID: | Q99PI8 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 51 kDa / 60 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | 293, HepG2 |
Background
Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Mediates axonal growth inhibition and plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG.
Images
| Western blot analysis of RTN4R (GB114985) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
