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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Otx2 rabbit polyclonal antibody |
Gene Name: | Homeobox protein OTX2 |
Synonyms: | Orthodenticle homolog 2, Otx2, Otx-2, CPHD6, MCOPS5, Orthodenticle 2 |
Immunogen: | Recombinant protein corresponding to Mouse Otx2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | P80206, Q64201 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1:600-1:1200 | embryonic mouse, embryonic rat, eye |
Background
The orthodenticle homeobox 2, encoded by OTX2 gene, is a key transcription factor in developmental processes. In particular, it is required for the early specification of the brain and the embryonic development of sensory organs, including the, pineal gland, pituitary gland, inner part of the ear, eyes, and optic nerve. In later stages, it is important for maintaining intact retina and brain function. In addition, it acts as a transcriptional repressor and a gatekeeper of myogenic and neuronal differentiation in medulloblastoma cells.
Images
| Immunohistochemistry of paraffin embedded mouse embryonic mouse using OTX2 (GB112574) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse eye using OTX2 (GB112574) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded rat embryonic rat using OTX2 (GB112574) at dilution of 1:600 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse embryonic mouse using OTX2 (GB112574) at dilution of 1:600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
