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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PERK rabbit polyclonal antibody |
Gene Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
Synonyms: | EIF2AK3, PEK, PERK, WRS ,eukaryotic |
Immunogen: | Recombinant protein corresponding to Mouse PERK |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 140 kDa |
Observed MW. | 140 kDa |
Uniprot ID: | Q9Z2B5 , Q9NZJ5 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse | 1: 500-1: 1000 | skin, brain |
Background
Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins.
Images
|
Western blot analysis of PERK (GB11510) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
