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Anti-PGRMC1 Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PGRMC1 rabbit polyclonal |
Gene Name: | Membrane-associated progesterone receptor component 1 |
Synonyms: | HPR6.6, MPR, PGRMC, PGRMC1, Progesterone binding protein, Progesterone receptor membrane component 1 |
Immunogen: | Recombinant protein corresponding to Mouse PGRMC1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 22 kDa |
Observed MW. | 22 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse | 1: 300-1: 800 | testis |
Background
Progesterone receptor membrane component 1 (PGRMC1) is a member of a multi-protein progesterone-binding complex. However, PGRMC1 shares homology with cytochrome b5-related proteins rather than hormone receptors . It is a heme binding protein with biding sites for Src homology (SH2) and SH3 domain-containing proteins . PGRMC1 is overexpressed in a variety of cancers, and thus represents an important biomarker for cancer progression and a potential target for anticancer drugs . In nonmalignant tissues, PGRMC1 is highly expressed in the liver and kidney.
Images
 | Western blot analysis of PGRMC1 (GB113216) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
