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Anti-PHF19 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | PHD finger protein 19 |
Synonyms: | hPCL3, MTF2L1, PCL3, PHD finger protein 19, Polycomb like protein 3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PHF19 |
Uniprot ID: | Q9CXG9 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 65 kDa / 72 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 2000-1: 3000 | kidney, brain |
Background
Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2).
Images
| Western blot analysis of PHF19 (GB115028) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
