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Anti-PNN/DRSP Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PNN/DRSP rabbit polyclonal |
Gene Name: | Pinin |
Synonyms: | Pnn, DRSP, DRS protein, Nuclear protein SDK3, SR-like protein, 140 kDa nuclear and cell adhesion-related phosphoprotein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PNN/DRSP |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 600-1: 1200 | placenta, lung, kidney, duodenum, fetal mouse |
IF | Human, Mouse, Rat | 1: 400-1: 800 | para-cancer lung, lung, kidney |
Background
PNN, also named as DRS or 140 kDa nuclear and cell adhesion-related phosphoprotein, is a 717 amino acid protein, which belongs to the pinin family. PNN localizes in the plasma membrane and is expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. PNN is expressed strongly in melanoma metastasis lesions and advanced primary tumors. PNN as a transcriptional activator binds to the E-box 1 core sequence of the E-cadherin promoter gene. PNN is involved in the establishment and maintenance of epithelia cell-cell adhesion. PNN is a potential tumor suppressor for renal cell carcinoma.
Images
| Immunohistochemistry analysis of paraffin-embedded human placenta using PNN (GB112523) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat placenta using PNN (GB112523) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded mouse lung using PNN (GB112523) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat lung using PNN (GB112523) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded mouse kidney using PNN (GB112523) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat kidney using PNN (GB112523) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded fetal mouse using PNN (GB112523) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded rat duodenum using PNN (GB112523) at dilution of 1: 1200 |
| Immunofluorescent analysis of paraformaldehyde-fixed human para-cancer lung using PNN (GB112523) at dilution of 1: 800 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse lung using PNN (GB112523) at dilution of 1: 800 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat lung using PNN (GB112523) at dilution of 1: 800 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse kidney using PNN (GB112523) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
