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Anti-PTPN14 Rabbit pAb (100 μl)
| Reactivity: | M & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Tyrosine-protein phosphatase non-receptor type 14 |
Synonyms: | PEZ, PTP36, PTPN14 |
Immunogen: | Recombinant protein corresponding to Mouse PTPN14 |
Uniprot ID: | Q62130 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cytoskeleton, Nucleus |
Predicted MW. / Observed MW. | 135 kDa / 160 kDa |
Product Usage Information
WB | Mouse | 1: 800-1: 1200 | placenta |
IHC/IF | Human | 1: 1000-1: 2000 | endometrial cancer, placenta |
Background
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
Images
| Western blot analysis of PTPN14 (GB114467) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human endometrial cancer using PTPN14 (GB114467) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human placenta using PTPN14 (GB114467) at dilution of 1: 1000 |
| Immunofluorescence analysis of paraffin embedded human placenta using PTPN14 (GB114467) at dilution of 1: 1000 |
| Immunofluorescence analysis of paraffin embedded human tonsil using PTPN14 (GB114467) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
