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Anti-Parkin Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | E3 ubiquitin-protein ligase parkin |
Synonyms: | AR JP, LPRS2, PARK2, Parkin, Parkinson disease protein 2, PDJ, PRKN, Parkinson juvenile disease protein 2, Parkin RBR E3 ubiquitin-protein ligase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Parkin |
Uniprot ID: | Q9WVS6 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus, Endoplasmic reticulum, Mitochondrion |
Predicted MW. / Observed MW. | 52 kDa / 52 kDa |
Product Usage Information
IHC/IF | Human, Mouse | 1: 150-1: 450 | pancreas, colon cancer, renal carcinoma, brain |
Background
Parkin, a RING-type E3 ubiquitin-protein ligase, is involved in the ubiquitination pathway and contributes to protection from neurotoxicity induced by unfolded protein stresses. Its ubiquitin-protein ligase activity promotes the degradation of a viariety of proteins including itself. Mutations in Parkin are implicated in the pathogenesis of autosomal recessive familial Parkinson's disease. It has 8 isoforms produced by alternative splicing.
Images
| Immunohistochemistry analysis of paraffin embedded human pancreas using parkin (GB114834) at dilution of 1: 150 |
| Immunohistochemistry analysis of paraffin embedded mouse brain using parkin (GB114834) at dilution of 1: 150 |
| Immunohistochemistry analysis of paraffin embedded human colon cancer using parkin (GB114834) at dilution of 1: 150 |
| Immunohistochemistry analysis of paraffin embedded human renal carcinoma using parkin (GB114834) at dilution of 1: 150 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
