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Anti-Pyrin Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Pyrin |
Synonyms: | FMF, Marenostrin, Mediterranean fever, MEF, MEFV, Pyrin, TRIM20 |
Immunogen: | Recombinant protein corresponding to Mouse Pyrin |
Uniprot ID: | Q9JJ26 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 86 kDa / 60 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 500 | ovary, lung |
Background
Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation.
Images
| Western blot analysis of MEFV (GB114534) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
