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Anti-RASSF1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Ras association domain-containing protein 1 |
Synonyms: | 123F2, NORE2A, RDA32, REH3P21 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Rassf1 |
Uniprot ID: | Q99MK9 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 39 kDa / 43 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 800-1: 1200 | kidney, skin, liver |
Background
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles,
Images
| Western blot analysis of RASSF1 (GB114356) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
