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Anti-REXO2 Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Oligoribonuclease, mitochondrial |
Synonyms: | CGI 114, REX2, REXO2, RFN, RNA exonuclease 2 homolog, SFN, Small fragment nuclease, SMFN |
Immunogen: | Recombinant protein corresponding to Mouse REXO2 |
Uniprot ID: | Q9D8S4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 27 kDa / 28 kDa |
Product Usage Information
WB | Human, Mouse | 1: 1000- 1: 2000 | heart, liver |
Background
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides . Binds and degrades longer oligonucleotides with a lower affinity (By similarity). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (By similarity). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome . Essential for embryonic development.
Images
| Western blot analysis of REXO2 (GB114183) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
