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Anti-RGS14 Rabbit pAb (100 μl)
| Reactivity: | H,M & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Regulator of G-protein signaling 14 |
Synonyms: | Regulator of G-protein signaling 14, RGS14 |
Immunogen: | Recombinant protein corresponding to Mouse RGS14 |
Uniprot ID: | P97492 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. / Observed MW. | 60 kDa / 68 kDa |
Product Usage Information
WB | Human, Mouse | 1: 300-1: 500 | brain, lymph node |
IHC/IF | Mouse, Rat | 1: 600-1: 1200 | hippocampus |
Background
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3.
Images
| Western blot analysis of RGS14 (GB114545) at dilution of 1: 500 |
| Western blot analysis of RGS14 (GB114545) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded mouse hippocampus using RGS14 (GB114545) at dilution of 1: 600 |
| Immunofluorescence analysis of paraffin embedded mouse hippocampus using RGS14 (GB114545) at dilution of 1: 600 |
| Immunofluorescence analysis of paraffin embedded rat hippocampus using RGS14 (GB114545) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
