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Anti-Rab1A Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Ras-related protein Rab-1A |
Synonyms: | RAB1, RAB1A, Ras related protein Rab 1A, YPT1, YPT1 related protein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse RAB1A |
Uniprot ID: | P62821 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 23 kDa / 28 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 1000 | liver, colon |
Background
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes . Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion . RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (By similarity). Regulates the level of CASR present at the cell membrane (By similarity). Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
Images
| Western blot analysis of RAB1A (GB114351) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
