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Anti-Reptin/TIP49B/RUVB2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | RuvB-like 2 |
Synonyms: | 48 kDa TBP interacting protein, CGI 46, ECP 51, ECP51, INO80 complex subunit J, INO80J, Repressing pontin 52, REPTIN |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Reptin/TIP49B/RUVB2 |
Uniprot ID: | Q9WTM5 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 800-1: 1600 | testis |
Background
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity . Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A . This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription .
Images
| Immunohistochemistry analysis of paraffin embedded mouse testis using RUVBL2 (GB114634) at dilution of 1: 1600 |
| Immunohistochemistry analysis of paraffin embedded rat testis using RUVBL2 (GB114634) at dilution of 1: 1600 |
| Immunofluorescence analysis of paraffin embedded mouse testis using RUVBL2 (GB114634) at dilution of 1: 800 |
| Immunofluorescence analysis of paraffin embedded rat testis using RUVBL2 (GB114634) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
